intermittent fasting with keto

Should You Practice Intermittent Fasting With or Without Keto?

If you are familiar with my blog, you are aware that as a general rule, I promote a moderate amount of carbs for women or, at least, cycles with a moderate amount of carbs. That’s why I wrote Intermittent Fasting Without Keto: Why It Works. Today, I want to spend more time helping you decide if you should practice intermittent fasting with or without keto. First, I am going to explain how intermittent fasting works to help you reach your health goals. Once you understand that, we can go over when intermittent fasting with keto will be most beneficial and when you should consider intermittent fasting without keto.

How Intermittent Fasting Works

I often talk about the benefits of intermittent fasting and how it helps you reach your health goals. Sometimes, I talk about insulin. Other times, the benefits of the stress of not eating or how your body can focus on healing when it’s not digesting food. There are many different ways fasting contributes to healing and weight loss. Today, I am going to spend more time helping you understand metabolic flexibility.

The Role of Metabolic Flexibility

I simple terms, metabolic flexibility is your body’s ability to go in and out of ketosis and adapt to changes in fuel sources and food availability. It can also refer to your body’s ability to switch from a resting state to an active state no matter what fuel sources are available.

From Fasting to Feeding

Metabolic flexibility does go hand in hand with insulin sensitivity. When you fast, your body doesn’t have to produce insulin, which means that gradually, as you fast more often or longer, your body will become more sensitive to the insulin it produces when you do eat. Besides insulin sensitivity, there is also a change of fuel source that occurs when you fast. As your body runs out of glycogen (the process of using glycogen is called “glucose oxidation“), it will start using fat stores to produce ketones. This is called “fatty acid oxidation“. The same thing happens when you do the keto diet, your body runs out of glycogen and produces ketones through fatty acid oxidation.

From Rest to Exercise

A similar situation occurs when you increase energy demand through exercise. Depending on the intensity of the exercise and the glycogen available in your muscle, your body may have to resort to fatty acid oxidation.

Fuel Metabolism Changes Based on Activity

This image demonstrates how eating increases glycogen storage, glucose oxidation, but reduces fatty acid oxidation. In a fasted state, fatty acid oxidation goes up, which means you start using ketones for energy. If you fast long enough, you will officially be in ketosis (if you measure your ketone levels, it means at least 0.5 mmol/L). Any type of activity increases glucose oxidation, decreases glycogen storage, and increases fatty acid oxidation.

Photo credit: Metabolic Flexibility in Health and Disease

Benefits of Ketogenesis

The process of ketogenesis is mostly regulated by insulin. As your body runs out of glycogen through fasting (or when you decrease carbohydrate consumption and increase the presence of fatty acids such as with the keto diet), your body produces ketones through fatty acid oxidation, and the process is called ketogenesis. Ketone bodies have the following benefits:

  • Food for your brain: Up to 70% of your brain can use ketones for fuel. The keto diet has been used to treat epilepsy, Alzheimer’s’ disease, and Parkinson’s disease. It can improve brain function, memory, and reduce migraine headaches.
  • Weight loss: Fewer cravings and less appetite contribute to weight loss.
  • Cancer prevention: The absence of glucose may help starve cancer cells.
  • Improvement of acne: It turns out that ketogenesis can help improve the health of your skin.

It is possible to reap these benefits through intermittent fasting without the keto diet. The question is: Should you practice intermittent fasting with keto or should you not follow the keto diet? Let’s talk about it.

How to Decide If You Should Practice Intermittent Fasting With Keto

Deciding whether to practice intermittent fasting with keto will have a lot to do with your level of experience with fasting, your health goals, and your gender.

Your Fasting Experience

If you are a fasting newbie, you may find it very beneficial to start with the keto diet. Transitioning with the keto diet will help you become more metabolically flexible without having to go hungry. It will make fasting a lot easier. Another option is to go on a modified fast. You could even do both! Start with a modified fast and do the keto diet for a week or so after your modified fast.

What is a Modified Fast?

The concept of a modified fast is based on the Fasting Mimicking Diet. The Fasting Mimicking Diet by Dr. Valter Long helps you benefit from prolonged fasting while eating some whole foods. A modified fast takes advantage of a short term severe calorie restriction (you would eat about 40-50% your regular calorie intake) and a low protein (9-10% of your macros), high-fat vegan diet (around 45% of your macros) to promote healing. Learn more about modified fasting by reading my post Modified Fasting: How You Can Benefit From Fasting Without Giving Up Food.

Fasting Experts

If you are comfortable with fasting, you don’t need to practice intermittent fasting with keto. It doesn’t mean you shouldn’t but you will be able to fast long enough to achieve ketosis without the keto diet. Once you have been in ketosis, it is easier to get back into it. With experience, you will notice that fasting for around 14-16 hours a day is all you need. To remain in ketosis longer, you can fast longer depending on how you feel. Some days I fast for 16 hours and some days, I fast for 22 hours. With experience, I have been able to gauge the most beneficial fasting period by paying attention to my energy level, my focus and my hunger signals.

Your Health Goals

I mentioned the benefits of ketogenesis (or ketosis) already. Deciding whether to practice intermittent fasting with keto or not will depend a lot on which benefits you are after. If you simply want weight loss, you can simply fast long enough to achieve ketosis for a time (I would recommend at least 18-20 hours each day). If you are after more serious therapeutic effects like the treatment of a disease like cancer or Parkinson, then doing intermittent fasting with keto would be beneficial at least until the disease is under control.

Your Gender

Women need carbs to support their hormonal function. Most fasting experts recommend that women at least ensure to have some refeeding periods with a moderate amount of carbs to support proper hormonal function. Women are more sensitive to the stress hormones released during fasting. They also have more kisspeptin, which is connected to reproductive function and makes them more sensitive to fasting. To learn more about how you can practice intermittent fasting safely has a woman, read How Intermittent Fasting Affects Women’s Hormones.

When You Should Practice Intermittent Fasting Without Keto

As a general rule, I recommend you just try whatever you want and decide if it’s working or not. However, there are a few cases when I would not recommend you combine intermittent fasting with keto:

  • During the last week of your menstrual cycle.
  • When breastfeeding.
  • If you suffer from thyroid dysfunction.

If you are not in one of these groups, it’s up to you. Do what you feel would work best. See how you feel and readjust if necessary.

Intermittent Fasting With or Without Keto Video

In Summary

Technically, the keto diet is simply a way to simulate fasting. When you fast, your body runs out of glycogen and switches from glucose to ketones for energy. On the keto diet, you can eat, but since you are eating such a low amount of carbs (50 grams or less), your body also runs out of glycogen. It is not necessary to combine intermittent fasting with keto to get the benefits of ketogenesis. However, the keto diet may help make fasting easier. Make sure you consider your health goals and your circumstances when you decide whether to include the keto diet to your lifestyle. If you are a woman, it’s probably best to make sure you include a moderate amount of carbs to your diet during the last week of your cycle at the very least. Otherwise, experiment for yourself and see what works!